Thermal Analysis in the Pharmaceutical Industry

Presented by Somayeh Sharafi

Thermal analysis includes all methods measuring some parameter during the heating of a sample. Thermal analysis of the sample is of great value for the pharmaceutical industry. Although not a new field, more advanced instrumentation, techniques, and applications are constantly appearing on the market and in the literature. Theoretically, almost any substance whether solid, semi-solid or liquid can be analyzed and characterized with thermal analytical techniques. In theory, all thermal analytical techniques simply measure the change of a specific property of a material as a function of temperature.

Developing properties of pharmaceutical materials

Thermal properties of pharmaceutical materials are critical characteristics for the advancement of nanomaterials in different applications. The poor thermal, mechanical, chemical, and physical properties of pharmaceuticals and their inherent permeability to gases and vapor have increased this interest. The thermochemical effect in pharmaceuticals does not only affect reactions, phase transitions, and melting behavior, but also shows a difference in thermal decomposition behavior of a material. In addition, environmental and storage factors such as humidity and temperature play an important role in the thermal stability of drugs and medicines. Hydrolysis may occur in a high humidity environment which will affect the effectiveness of some active ingredients. The use of humidity controlled thermal analysis gives the drug manufacturers an insight and allows simulation experiments on how drugs and medicines are affected by humidity and temperature.

Thermal decomposition behavior of Aspirin in water vapour atmosphere by HUM-STA-MS

This webinar will discuss the use of the Rigaku thermal analysis line including Differential Thermal Analysis (DTA), Thermogravimetry Analysis (TGA), Differential Scanning Calorimetry (DSC), Scanning Thermal Analysis-Mass Spectroscopy (STA-MS), and Thermomechanical Analysis (TMA).   This will explore reaction phase transitions, melting behavior, and decomposition behavior which allow pharmaceutical manufacturers to determine the effectiveness and timed release of medicinal compounds.

This webinar aired on December 15, 2022 @ 2:00PM GMT-3.

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