Abstract: The current cooling systems of internal combustion engine vehicles have several functions; in addition to removing excess heat from the engine, it plays an essential role in ensuring that the engine quickly reaches operating temperature and keeping the passenger compartment at the right temperature. Nanofluids possess better heat transfer properties so that current and future cooling systems can work more efficiently. The common coolant used in cooling systems is water or what equivalent substance; these coolants suffer from a decrease in thermal conductivity, which negatively affects internal combustion engine efficiency. This study presents an experimental investigation using iron oxide (Fe2O3) and tungsten trioxide (WO3) nanopowder suspension at a specific volume concentration in deionized water as proposed nanofluids. Thermal analytical calculations were conducted of the proposed nanofluids under laboratory conditions with validation of the results and comparison with previous studies. The study indicates an improvement in the heat transfer rate, Nusselt number and heat transfer coefficient, drop in the friction coefficient with an increase in Reynolds number, and convergence of the experimental and simulation results confirms the accuracy of the results. The current developments contribute to increasing the usability of new cooling media by the vehicles and the possibility of achieving greater efficiency.