Powders

• Utilization of brown rice flour as a functional ingredient in instant fried noodles

  Brown rice flour was utilized as a functional ingredient in instant fried noodles and their quality attributes were characterized from the standpoint of physicochemical characteristics. The pasting...

• Combined effect of silica fume and expanded vermiculite on properties of lightweight mortars

  In this study, properties of cement based mortars produced with vermiculite and silica fume were investigated at ambient and elevated temperatures. Physical, mechanical, thermal and micro structure...

• Characteristics of Fired Clay Bricks with Waste Marble Powder Addition as Building Materials

  Fired clay bricks lightened by adding up to 35 wt% waste marble powder have been produced by semi-dry pressing process. Chemical composition, phase identification, thermal behaviour and...

• Effect of Powder Characteristics for a Magnesium Based Metal Hydride Store

  The particle size and shape of commercially available MgH₂ have been characterised, together with those of ball milled MgH₂. These parameters have then been compared with those obtained for the...

• Investigation of the Influence of Inert Solids on Ignition Sensitivity of Organic Powder

  This work presents the results of the experimental characterization of the ignition sensitivity of solid inertant/combustible powders mixtures. Three inert solids (Alumina, Kieslguhr, Aerosil) and...

• Carbon Fiber / Expanded Polypropylene Composite for Isotropic Conductivity

  Lightweight and multifunctional materials are of interest in many industrial fields [1-15].  Electrical and thermal conductivities can be useful for applications such as the heat sink or...

• Enhanced thermal conductivity of polymer composites filled with hybrid filler

  This study aims at investigating package materials based on polymer matrix for microelectronics. The next generation package materials are expected to possess high heat dissipation capability in...

• Evaluation of the Blending Process of Pharmaceutical Granules with Magnesium Stearate by ESP

  Magnesium Stearate (MgSt) is a widely used lubricant for preventing tablet compression trouble. It is known that the powder characteristic of MgSt is different among MgSts manufactured by different...

• Effect of Varying Thermal Conductivity on Heat Conduction Through a Physical Model of a Hydride Bed

  This paper investigates the effect of implementing a varying effective thermal conductivity term on heat transfer simulations within a metal hydride (MH) reactor. The work presented utilises a 1D...

• Effusivity as a useful tool in Powder Characterization

  Join researchers from Long Island University's School of Pharmacy as they discuss their work in applying C-Therm's ESP system in powder characterization. Thermal effusivity is a powerful tool in...

• TCi’s Application in the Thermal Conductivity Characterization of Explosives

  Testing the thermal conductivity of most energetic materials is a challenge with more traditional techniques, as the required large volumes of material pose undesirable safety risks or the...

• Characterization of the Performance of Bin Blenders: Part 1

  In this series of articles, bin blender performance is comprehensively reviewed using both free-flowing and cohesive mixtures. In part 1, an introduction to tools and techniques is presented,...

• Monitoring Blend Uniformity with Effusivity

  The authors describe the measurement of the effusivity of blended and unblended commercial pharmaceutical formulations to effectively differentiate between materials and then to determine if the...

• In-line Monitoring tool for Magnesium Stearate Blending End-Point Determination

  In September 2004, the US Food and Drug Administration released a Process Analytical Technology (PAT) guidance document to encourage the pharmaceutical manufacturing industry improve their...

• Thermal PAT Tool for Blend Uniformity

  Process Analytical Technology (PAT) initiatives by the FDA have motivated vendors to introduce innovative, new technologies to the pharmaceutical field. A noteworthy example from Mathis Instruments...

• Standard Test Method for the Measurement of Thermal Effusivity of Raw and Process Materials

  This standard describes the method of use for a PAT system to measure a physical property (effusivity) that has practical application in monitoring blending (uniformity and lubrication), drying,...

• Evaluation and Characterization of Mixed Lubricant Systems

  Purpose: To investigate the physicochemical characteristics of mixed lubricant systems comprising of known ratios of polymorphs of magnesium stearate (MgSt) in direct compressible formulations....

• Thermal Effusivity as a PAT to Optimize Blend Uniformity

  In October 2003, FDA released a draft guidance that introduced PAT to the pharmaceutical manufacturing industry [1]. PAT is a science based approach that focuses on the improvement of manufacturing...

• Process Analytical Technology (PAT) Standardization Update

  Any parent will identify with the analogy between the development of Process Analytical Technology (PAT) and the development of a child. First, before there is a child, there is the desire to have...

• Magnesium Stearate Solution

  When tablets fail ... they fail at dissolution testing. That is too late in the process to make any changes. With advanced tablet presses that monitor hardness real time, the problem can still...

• Formulation and Process Engineering

  Mathis ESP is a powerful, new tool for formulation development and production scale-up. It is simple to use, and allows you to optimize formulations quickly and cost-effectively. Effusivity is an...

• Quality Control in Battery Manufacturing

  Three critical control points in battery manufacturing include: 1) blending quality; 2) drying end point determination and 3) porosity measurements. Overblending or underblending may result in...

• A Novel Technique for Determination of Real Time Blend Uniformity

  Purpose. To introduce a new technique for monitoring powder blend uniformity in a manner that allows on-line control. The existing blenders can be retrofitted to allow for real time monitoring...

• Stages of Technical Evaluation

  There are three stages that form part of any investigation of our effusivity instrument to determine its sensitivity to blend uniformity monitoring within a formulation. These stages have been...

• Blend Uniformity Group Phase 1

  Mathis Instruments Ltd. (Mathis) has developed a technology that has the potential to measure blend uniformity during mixing. The technology has been tried in an off line format internally and...

• Data Mining Collaboration: Effusivity vs %LC

  Effusivity does not measure the amount of active ingredient, but rather the uniformity of the major components in the blend. An assumption must be made that uniformly blended excipients will...

• Blend Uniformity Group Phase 2

  Blend-Tech (BT) has technology that has the potential to measure blend uniformity during mixing. The end goal is to work collaboratively with blender manufacturers on a solution that can be easily...

• Cost Recovery for Blend Uniformity Testing with Effusivity

  There are several components of potential economic benefit of improved blend uniformity testing common to any pharmaceutical company and an additional component for generic producers. Estimates...

• Effusivity of Edible Powders

  The Mathis Technology is an effective and simple instrument to determine powder blend uniformity. This is important to not only pharmaceutical companies (see B24) but also to food processors. A...

• Effusivity as a Method of Detecting Powder Homogeneity for Pharmaceuticals

  When powdered components are blended during drug production, timing is critical. If the blending period is too short, the agitation has been insufficient to produce a homogeneous product. If...

• Determining the Test Mass

  When the Mathis Technology is used to evaluate pharmaceutical powders, it is a requirement to understand
  the mass of the material tested to meet the FDA requirements that test samples be between 1...

• Application of Effusivity as PAT Tool for Roller Compaction

  The aim of this study was to examine the relationship between physical characteristics of compacted ribbons and their thermal effusivity in an attempt to evaluate the feasibility of using...

• Wet Granulation Endpoint Determination with Effusivity

  The objective was to determine end point wet granulation of microcrystalline cellulose (Avicel 101) using solid state rheological and effusivity measurements.

• Monitoring the Effect of Moisture on Dextrose with Effusivity

  Dextrose Monohydrate (Emdex®) is commonly used in pharmaceutical industry as a tabletting excipient for orally disintegrating tablets. The purpose of this study was to see the effect of moisture at...

• Additive Effect of Magnesium Stearate and Stear-O-Wet on Wet Granulation

  The purpose of this study was to determine the effect of magnesium stearate and stear-o-wet on wet granulation while adding the lubricants during the wet granulation process and then measuring the...

• Determination of Optimal Blending Time

  To understand the blending process and determine the optimal blending time for an experimental product using a PK blender equipped with thermal effusivity sensors. Compare the data obtained with...

• A Novel Technique for Raw Material Quality Control

  Powders are blended together for pharmaceutical product manufacture and the consistency of those powders is critical to the quality of the product. Typically four or more individual components are...

• Optimization of Technique for Nondestructive Evaluation of Powders

  Effusivity is a critical thermophysical property that can be measured during the production of powders. Since effusivity varies with the degree of mixing present in a blend of powders, the ability...

• Measuring Thermal Conductivity of Ceramics

  A recent development of the modified transient plane source (MTPS) technique offers an innovative solution to the traditional challenges of thermal conductivity measurement. Whether for development...

• Effects of Carbon Nanotubes on Properties of Poly Nanocomposites

  The C-Therm TCi Thermal Conductivity Analyzer is applied in characterizing the effects of surface-functionalized multi-walled carbon nanotubes (MWNTs) on the properties of poly(dimethyl siloxane)...

• Measurements in Motion

  Mathis Technology is a useful and effective instrument to determine blend uniformity of powders for pharmaceuticals, food and other industries. When powders are blended during production, timing is...

• Thermal Conductivity Measurement of Metal Hydrides

  There are extensive efforts underway worldwide to develop inexpensive and practical hydrogen storage materials for the implementation of a hydrogen-based energy economy. Metal hydrides are leading...

• Thermal Conductivity of Ammonium Nitrate

  In recent years, there have been numerous incidents involving runaway reactions with ammonium nitrate emulsion (ANE) explosives. In most cases, thermal explosions have occurred during abnormal...

• Thermal Effusivity as a Possible Indicator of Particle Size and Particle Size Distribution

  Characterization of three chemically identical but physically different powder samples yielded unexpected but logical results. Thermal effusivity values appeared to correlate with particle size,...

• Testing Powders

  This application note presents the advantages of using the Mathis Instruments TC-30™ to characterize powder samples. The Mathis Instruments TC-30™ is a flexible, high performance, rapid,...