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Investigate the Effect of Solvents on Wet Granulation of Microcrystalline Cellulose

Since decades, granulation is operational as a critical size enlargement process for powder agglomeration in tablet manufacturing. Dry granulation, melt granulation and wet granulation are some of the most common techniques utilized for granulation in the pharmaceutical industry. However, in pharmaceutical tablet production, wet granulation is the most frequently used process consisting of agglomerating powder particles with a liquid binder, in a fluidized bed, high shear mixer or low shear mixer. All required features for compression, namely a good flow, appropriate compatibility and uniform drug distribution can be achieved using wet granulation and hence it is extensively employed granulation technique.

This paper highlights application of the C-Therm TCi Thermal Conductivity Analyzer.

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